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While LN rats have normal blood pressure, LL rats have late onset hypotension while LH rats are spontaneously hypertensive by 5 weeks of age [ 4, 5].
The diagnosis of sepsis is further defined by the presence of diarrhoea with at least two other parameters that could include tachycardia (≥ 90 bpm), pyrexia (temperature ≥ 38°C), tachypnea (≥ 20 breaths per minute) or new onset hypotension.
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All 3 postoperative deaths were suspected to be PEs with sudden-onset hypotension and respiratory distress, though definitive diagnosis or post-mortem examination was not available at the time.
Opioid analgesics are the most widely used drugs to treat moderate to severe pain, yet in addition to profound analgesia, these agents also produce significant side-effects consisting of miosis, sedation, nausea and vomiting, cognitive impairment, constipation, rapid-onset hypotension and on occasion life-threatening respiratory depression (1– 4).
The second agent had to be started within 24 hours of the first antibiotic or within 24 hours of the onset of hypotension (if the first agent was initiated before hypotension was documented).
The route of administration (currently FDA-approved only for intravenous administration) and the rapid metabolic conversion of Amifostine combine to yield high systemic levels of WR-1065 and facilitate the onset of hypotension.
However, neutropenia was complete by day 1, while onset of hypotension was more gradual.
The contribution of valproate to the onset of hypotension is consequently difficult to determine.
Septicemia can result in rapid onset of hypotension, multiorgan dysfunction shock, peripheral ischemia, limb loss, and death.
Time from onset of hypotension to both appropriate antibiotic therapy and line removal were assessed, and mortality differences observed.
The onset of hypotension was not recorded, and therefore, we cannot determine timing of interventions from that event.
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