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Two patients developed acute onset grade 3 dyspnoea and cough in cycle 5, their symptoms resolved in 1 week and no further gemcitabine was given.
Consistent with ependymoma subgroups based on aCGH profiles, ependymoma gene expression profiles are significantly associated with tumor location, patient age at disease onset, grade, and retrospective risk for relapse [6], [48], [73], [106].
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One patient was taken off study after experiencing early-onset grade 3 diarrhea and palmar-plantar erythrodysesthesia (PPE), and another patient decided to withdraw consent during cycle 1 of treatment due to grade 1 nausea.
The objective of the study was to evaluate separetely in each of the two study arms the safety and efficacy profiles of the two regimens in terms of the onset of grade 3 4 side effects (at least two sequential episodes of grade 3 or one episode of grade 4 neutropenia or diarrhoea) and the response rate (RR).
Median time to onset of grade 3 4 neutropenia was 13 days after the infusion.
In two out of those three patients, CMV replication occurred after onset of grade II-IV acute GVHD.
In conclusion, the cumulative doses of oxaliplatin linked to the onset of grade ≥3 NSAEs were higher in Asian patients than in Western patients.
According to data reported by Smith et al. (22), the onset of grade 3 proteinuria was common in the maintenance period.
Our study showed that Gln significantly reduced the incidence and delayed the onset of grade ≥3 ARIE, reduced the need for unplanned treatment breaks, and reduced hospitalization.
The onset and grade of diarrhea during whole-pelvic irradiation were recorded as small-bowel toxicity up to 39.6 Gy in 22 fractions.
Late radiation toxicities were reported in two patients: one patient in DL1 with the onset of grade 1 small/large intestine toxicity 148 days from the start of the RT, and the other patient in DL2 with onset of grade 2 liver toxicity 121 days from the start of RT.
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