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Pretreatment with MPEP, at all doses, delayed the onset for the first seizure episode induced by pilocarpine in rats.
The symptom onset for the first cases was retrospectively estimated between 26 and 27 June, i.e. three months before the first cluster was identified17.
The date of illness onset for the first patient in Shanghai was February 18, followed by March 7 , 15 and 19 for Zhejiang, Jiangsu, and Anhui provinces, respectively.
The age at onset for the first malignancy was relatively high, as the estimated penetrance at 40 years of age ranges between 77%–100% [ 5].
For each outbreak, information on etiology, number of cases, date of symptoms onset for the first and last cases, affected counties, and whether the outbreak occurred in an institutional setting such as a nursing home was provided.
To extract features from premovement signals, first, epoching was performed with a window of −2 s to 0 s of movement onset (EMG onset) for the first session of each ECoG data type (hand grasping and elbow flexion) for all subjects.
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One of the regressors coded for onset of the first stimulus; another one for all other stimuli onsets.
Next, the onset of the deviating phonemes, which was the onset of the closure period for plosives and the onset of the first period for nasals, was determined in the acoustic signal.
The release of eIF4E from its translational repressor 4E-BP and the subsequent formation of the eIF4E/eIF4G complex correlate with the rapid increase of protein synthesis triggered by fertilization and are required for the onset of the first mitotic division of embryonic development [32], [33].
The median age for the onset of the first melanoma was 42 years (range 19 70).
They observed that the median age for the onset of the first symptoms was 2.2 years; approximately 30%% of these patients presented CKD at diagnosis, and 50%% required renal replacement therapy by age 15 [ 15].
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