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Prior work might not have revealed the same degree of heterogeneity because of the use of shorter incubation periods, use of more potent drugs or combination therapies, or loss of the most severely affected mice before treatment onset (Driver et al., 2012; Rosenthal et al., 2012; Irwin et al., 2014).
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This paper describes an investigation of the influence of the position of a forward vehicle and following vehicle on the onset of driver preparatory behavior before making a right turn at an intersection.
Expression of SCA3trQ78 in differentiated photoreceptor neurons with the adult-onset photoreceptor driver, rhodopsin-1-GAL4 (rh1-GAL4), allowed us to examine degeneration slowly over time in the adult, and is more sensitive for analysis of changes in protein levels.
We used the late-onset rhodopsin (rh1-Gal4) driver that allows sensitive analysis of inclusion formation (11, 13).
A more recent study by Gao et al. used DOP-PCR to amplify genomic content from 1000 cells and reported that the majority of subclonal CNV occurs shortly after the onset of the primary driver mutation in breast cancer.
This papers presents an artificial intelligence based system which could detect early onset of fatigue in drivers using heart rate variability (HRV) as the human physiological measure.
The findings show that the abrupt onset of beeping startles drivers, causing them to take their foot off the accelerator and, momentarily, deviate from the correct trajectory within the lane.
Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies.
RAS mutations and RET rearrangements are unlikely to act as molecular drivers for onset of malignancy as they are already present in benign thyroid neoplasms [ 13, 14].
For many of them, we're learning something that we may not have quite expected from the onset: retail is a great driver of sales and profitability.
Recent studies revealed tumour heterogeneity as an important driver for the onset of resistance (Hanahan and Weinberg 2011; Nagy and Dvorak 2012; Saunders et al. 2012; Yachida et al. 2010; Zhu et al. 2014), which can make the whole tumour as resistant to treatment once the first wave of treatment has eliminated the weak tumoural cells, leaving the resistant ones alone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com