Only well-differentiated cultures (>2 weeks old) were used in these studies.
The clinical question is what to do when, in a diagnostic biopsy, only well-differentiated DCIS clinging/micropapillary type is detected.
Importantly, in vitro MS-275 pretreated cells failed to form teratocarcinomas developing only well-differentiated teratomas, with a prevalence of epithelial and neural tissues, such as small neuronal tubes (Fig. 7C8,9) and absence of respiratory epithelium, cartilage and smooth muscle, compared to control.
I-WBS is more specific and sensitive than a bone scan but only for well differentiated thyroid cancer [ 4].
This could indicate that FANCA is involved only in well differentiated breast cancer.
Interestingly, basal cell and squamous cell carcinomas were found to express cystatin E/M only in well differentiated cells.
These patients, which constitute approximately 5% of solid tumor-related cases, typically present with disseminated disease but have no clinically detectable primary tumor or only a small, well differentiated lesion that is found at autopsy [ 10].
Thus, poorly differentiated and highly proliferating adenocarcinoma of the breast, colon and prostate were strongly labelled by the pThr187-p27 Ab, whereas "plain p27" staining was only retained by well differentiated neoplasms.
As a general rule, the expression of the two forms of p27 was alternative and dependent on the degree of tumour differentiation, recapitulating the pattern featured by normal and dysplastic tissues; phospho-p27 strongly labelled aggressive tumours, whereas "plain p27" staining was only retained by well differentiated tumours.
Only in a subset of well differentiated and progesterone receptor-positive tumors has Bcl-2 been reported to enhance disease progression [ 35].
