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The ER diffusion barrier seems to become critical for aging only upon induction of ER stress.
Using the same primer sets we observed MYC occupancy in the promoter of AQP1 and SERPINE1 only upon induction of wtBRG1 expression (Fig 2C).
This band was present only upon induction of expression of the modified SUMO gene (Fig 1A, compare lanes 2 and 4), suggesting that it might represent SUMOylated Tpz1.
We show that aberrant localization and recruitment of FUS into stress granules (SGs) is a prerogative of the FUS mutant proteins and occurs only upon induction of stress in both undifferentiated iPSCs and spinal cord neural cells.
A phenotype, thus far observed in mice only upon induction (e.g. body pinch or drug exposure; Amir, 1986; Chaperon & Thiebot, 1999) is catatonia/catalepsy, a state of immobility where mice persist in an externally imposed abnormal posture for a prolonged time period.
In 1999, Chen and Capecchi [ 12] reported mild to no phenotypic changes in mammary glands of HOXA9/ HOXB9/ HOXD9 knockout mice; these triple-knockout female mice showed hypoplasia of the mammary glands but only upon induction of pregnancy and lactation; however, they did not develop tumors.
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The expression of these PRC2 target genes is repressed in ES cells and only activated upon induction of differentiation.
For two papers which argue that EPR did not depend upon counterfactual reasoning but only upon ordinary induction, see d'Espagnat (1984) and Shimony (2001).
Furthermore, using our model locus assay, we also show transcription dependence of the elevated S9.6 signal as it occurs only upon galactose induction of transcription in the region.
These oscillations were highly reproducible and showed only minor difference upon induction by IPTG (Figure S1B).
We isolated the strains with interesting biological and biochemical phenotypes: constitutive secretion with cytotoxicity, delayed cytotoxicity, delocalization of the tip protein only upon low-calcium induction, and low secretion levels of translocators but not of effectors.
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