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In the J dataset, only two pathway out of four overlaps those found using IL23R.
The Weinberg lab has described that tumorigenic transformation of normal human fibroblasts requires the mutation of six different signaling pathways, whereas mouse fibroblasts require only two pathway mutations (p53 and Raf) to bypass senescence and transform (81).
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Only two pathways are shared but highly populated: IL9 signaling, a cytokine made by activated T cells, and RAN signaling linked to transport of RNA and proteins from the nucleus.
However when adjusting for multiple testing using the Bonferroni method only two pathways significantly targeted by genomic alterations are also highly associated with survival;""Hypoxic and oxygen homeostasis regulation of HIF-1-alpha" [38], [39], [40], and Glycosaminoglycan degradation [refs].
In all four comparisons, there were only two pathways in common (Table 3).
This is due to fact that only two pathways were enriched in 130T using this analysis.
GTA identified only two pathways which significantly correlated with miR-26a, and 10 pathways with EZH2 mRNA expression (Table 3).
However, only two pathways, those for ribosome biogenesis and carotenoid biosynthesis, were significantly enriched in the shoot (Table 3).
The KEGG Pathways enriched for enzyme activities unique to L. bicolor (Table 3) consists of only two pathways.
Surprisingly, only two pathways for uptake, assimilation and utilization of inorganic and organic phosphonates were found in the genome.
In the past, in fact, only two pathways were identified, including downregulated genes involved in neurosecretion and excitability [ 31].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com