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This suggests that D-loop epigenetic modification is only partially established by these enzymes.
Whilst some hyper-virulent isolates have been described, the relationship between genetics and disease outcome has been only partially established.
While genetic studies have shown that while H3K9 methylation is completely responsible for establishing DNA methylation in heterochromatic regions of Neurospora, this correlation is only partially established in Arabidopsis [ 6, 7].
Although integratomic approaches are only partially established yet and have several drawbacks, including already mentioned heterogeneity of input data, we believe that such approaches are a reasonable and at the moment among the most promising ways for hypothesis generation, which should be further experimentally validated in animal and/or human populations.
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In addition, to optimize confidence in our data used to inform the RED, we used only established and partially established difficulties based on the literature review (RQ1) that included only primary research reports.
As summarized in Table 1, we found that most of the reported difficulties with experimental design could be classified as established, while only a few met our criteria of partially established, due to limited evidence.
In dy3K/δE3 mice, basement membrane assembly was only partially re-established.
This difficulty is classified as partially established, because it was found in only one quasi-experimental study with undergraduate students who were not science majors.
With limited evidence, a partially established difficulty merits further research.
The excess cardiometabolic risk associated with abdominal adiposity is only partially explained by established risk factors; systemic low-grade inflammation may represent an additional less extensively explored mechanism (3, 4).
He left a legacy of meticulously restored historic monuments; founded the Orchestre de Paris; installed Maillol's sculptures in the Jardin du Carrousel; revitalized the Marais; and embarked on an ambitious project, only partially realized, to establish regional arts centers in every department.
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