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Unlike mammals, where only one prion protein of unknown function has been described, yeast contain several prion protein determinants [ 11, 12].
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However, of all 13 mutated residues isolated in Sse1 identified as altering prion propagation, only one (E504) is not conserved in Sse2 (Q504).
Only one class was efficient against prions.
Until recently, only one form of naturally occurring cattle prion disease was recognized.
The diagnosis was extraordinarily rare — prion diseases, of which F.F.I is one, afflict only one in a million people.
Curiously, certain cell lines can faithfully propagate different prion strains, while other cell lines are permissive to only one strain28, 29.
Creutzfelt-Jacob disease is the most common human prion disease, but it's still relatively rare, affecting only one in one million people.
In this case, if only one among the sequences introduced by the user happens to bear prion-like domains, the output will correspond to a Detailed Output Page with the specific information for the protein.
Prion-like domains can access two distinct aggregated states, only one of which is amyloid-like.
In these inherited cases a mutation in a gene designated PRNP), which encodes the prion protein PrP, is passed from parent to child in a dominant fashion (i.e., only one of the two copies of the gene that are inherited one from each parent need be mutated for disease to occur).
The diagnosis was extraordinarily rare prion diseases, of which F.F.I is one, afflict only one in a million people.
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CEO of Professional Science Editing for Scientists @ prosciediting.com