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The RASCAL II study demonstrated a significant influence on survival of only one mutation, G12V, especially in Dukes C patients (Andreyev et al, 1998, 2001).
In fact, only one mutation was identified having an evident pathogenetic effect on protein function.
Only one mutation was identified discriminating between B. mallei and B. pseudomallei.
Our YDHS database contains only one mutation for haplogroup D2a; namely M116.1.
Importantly, only one mutation in the framework may be necessary to recover the binding capability of a humanized antibody.
We detected two mutations in eight patients from six families and only one mutation in four patients from three families.
Only one mutation, occurring in the internal DNA pilot protein H, was completely repeatable, and it appeared to be a necessary stepping stone toward further adaptive change.
However Rushlow et al. reported tumors with only one mutation in RB1 (RB1+/−) and even cases with two functional alleles (RB1+/+) [22].
There are 10 mutations stored in YDHS database for R1b1a2 haplogroup and interestingly only one mutation hits a gene region, namely eukaryotic translation initiation factor 1A (EIF1AY).
Only one mutation was detected in this patient.
There is only one mutation at position 30 (D30N).
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CEO of Professional Science Editing for Scientists @ prosciediting.com