One group contains 10 poorly differentiated samples and only one well-differentiated sample, whereas 83% of the well-differentiated samples group in the other, second cluster.
Most of the subgroups were composed of varieties from both the Bahau and Kayan regions, with only one subgroup differentiated geographically: Pop2 had 23 out of 24 accessions coming from the Bahau river (Supplementary Table 3).
Accordingly, simple patterns of regulation may be expected for genes that are either constitutively expressed or expressed only in one differentiated cell type, while complex regulation may be expected for genes which are expressed in early stages of development, which produce more than one unique product or which are directly responsive to environmental and/or multiple input (Wray et al. 2003).
One possibility is that both STIM1 and TRPC1 exist in two states in proliferating N-type cells and in only one state in differentiated N-type cells.
Although these culture conditions give rise to only one subset of differentiated cells and do not represent the full heterogeneity of macrophages or DCs in vivo, it still is the most efficient way to obtain human antigen presenting cells.
Only one locality had individuals highly differentiated, with little nuclear admixture, and population substructure, but overall, P. chilensis showed a greater degree of homogeneity than expected given its life history.
The IIA and IID are transient embryonic isoforms that include an additional cysteine-rich domain encoded by exon 2. The IIA and IID transcripts are co-expressed during chondrogenesis then decline and the IIB isoform is the only one expressed and synthesized in fully differentiated chondrocytes.
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VPA activated the expression of only one GP isoform, GP-BB, in differentiated muscle cultures from KI mice, yet this isoform seemed to have beneficial functional consequences because it decreased intracellular glycogen accumulation.
Staha recycled seems, thus, more differentiated from the formal system group than the two Staha populations that had been grown on-farm for only one generation.
