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Objectively speaking, the weakness in this model is that it is based on only one database and is the product of one group.
Although Medline includes a great number of journals on healthcare research, the search in only one database might be judged as limitation.
Gathering data from multi-sources is useful to reveal the structure of network rather than to use only one database.
CTD is only one database with toxicogenomic information, although it is the most important one for toxicological questions.
Notably, the literature search was inadequately reported, narrow search terms were used, only one database was searched, there were no clear eligibility criteria for study selection, and the risk of bias of included trials was not assessed [22,23].
Additionally, we searched only one database, PubMed.
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Using this service, user-specified ID code/s from reference database can be mapped on to equivalent ID code/s from only one target database at a time.
To the best of our knowledge, only one other database exists that focuses on hormones and receptors but this puts less emphasis on the underlying network (HMRbase, status 2009 [ 15]).
Right now it is too soon to tell but I would certainly like to combine my IM, email and VoIP into one client and more importantly have only one contacts database that I can synch with my mobile phone.
Use of only one citation database for our literature search.
Finally, we tested only one French database population, and a replication in a different ICU population could have been useful.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com