Thus, removing host mimics from vaccine constructs could be a crucial step toward designing not only safer but also more efficacious HIV vaccines.
Tracing the ontogeny of ACOA behavior using measurable units of response not only makes scientific sense, but also is clinically more efficacious for designing treatment intervention.
A full, more efficacious agonist would only need to occupy only a few receptors in order to elicit a response, and thus the EC50 value will be lower than the KD value.
Of importance, the trial will not only indicate whether PFT is a more efficacious alternative to CFT, but moderator analyses will indicate whether there are specific patient or family characteristic that are useful in guiding the selection of treatment approach.
These findings can be exploited to, design more efficacious vaccines not only against HIV-1, but many chronic infections where high, avidity CD8+ T cells help protection.
Doublets are more efficacious but more toxic than FU alone, so it is uncertain whether it is better to start with a doublet or to use the drugs sequentially; in addition, doublets are more efficacious than FU alone only in patients under age 70, with a good performance status (PS) and relatively normal serum chemistries (Knight et al, 2000).
In conclusion, appraisal of the immune hallmarks of cancer, and of the possible countermeasures, opens the doors not only to widespread cancer immunoprevention but also to innovative and more efficacious cancer immunotherapies.
There is, therefore, a need for new and more efficacious agents, targeted not only at treatment, but also at prevention of the disease, its progression, and its associated complications.
A recent study conducted within Head Start classrooms suggests that fluoride-xylitol toothpastes are not more efficacious than fluoride-only toothpastes [ 63].
