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Interestingly, the chickens with the highest pre-challenge anti-LOS antibody level, had only modest responses post-infection.
However, clinical trials have demonstrated only modest responses, and the reasons for these outcomes remain unknown.
One should note there is general agreement that recombinant IFNβ produces only modest responses in some patients.
By way of example, it is important to recall that initial use of tamoxifen, a failed contraceptive, to treat unselected populations yielded only modest responses for some patients with metastatic breast cancer [ 45].
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The relatively small sample size, only modest response rate to this survey, and lack of information regarding respondents' exposure to BD patients are significant limitations.
First, the study suffered from only modest response among controls (cases 76%, controls 57%).
Interestingly, MDA231 cells (TNBC) exhibited only modest response to 3-BrOP for yet unknown reasons.
Although complete pathological response rates of 10 25% can be achieved, more than one-third of patients either do not respond or show only modest response to treatment [ 6].
Disappointingly, trials of single-agent inhibitors of IGF-1R and downstream targets have generally shown only modest clinical responses (Jin et al, 2013).
In addition, clinical trials involving Rapamycin or other mTOR inhibitors have shown only relatively modest responses in 7 30% of cancer patients [ 6- 8].
Despite of only modest objective response rates according to the Response Evaluation Criteria in Solid Tumors, several studies showed encouraging results in terms of prolongation of the time to progression, disease stabilization, and survival.
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