Sentence examples for only modest activities from inspiring English sources

All the complexes were screened in vitro against Mycobacterium tuberculosis and exhibited only modest activities in the micromolar range.

Although only modest activities were observed, these results suggested that a new series of bioactive cryptophycin analogues might be available by structural modification of the central ring system of the cryptophycins.

Conversely, the reported fungal DyP-type peroxidases are known to be highly active against anthraquinone dyes and display only modest activity against standard peroxidase substrates and azo dyes (Kim and Shoda 1999; Sugano et al. 2000).

Erythropoiesis-stimulating agents (ESAs), androgenic steroids, thalidomide, lenalidomide, splenectomy, and prednisone are only modest activity in reversing anemia and ruxolitinib, pacritinib and fedratinib typically worsen anemia4,5,6,7.

However, thus far α-PD-1 or α-PDL-1 antibodies have shown only modest activity as monotherapies36, 37. We have previously shown that genomic alterations in the Ras/MAPK pathway correlate with lower TIL infiltrate in TNBC15, raising the hypothesis that targeting MEK may enhance TIL infiltrate and thereby potentiate the efficacy of immunotherapy with the ultimate aim of improving survival.

As noted above, clinical investigations of DAC inhibitors in B-cell malignancies have shown only modest activity.

Gemcitabine-based chemotherapy for locally advanced or metastatic PDAC has only modest activity with a small survival benefit [3].

The first-generation CDK inhibitors, flavopiridol and CY-202, are in late-stage clinical trials, and have only modest activity [16].

SPI-77 demonstrates only modest activity in patients with NSCLC.

In conclusion, temsirolimus appears to have only modest activity with a manageable toxicity profile in advanced NEC.

When tested as monotherapy in pre-clinical models of colon cancer, these compounds demonstrate only modest activity.