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In order to avoid this, the regression was limited to those parameters which were known with least certainty and only moderate changes were allowed.
We created mutant pairs of the Sln1-Ypd1 complex interface that caused major compensating changes in the association (kon) and dissociation (koff) rate constants (kinetic perturbations) but only moderate changes in the overall complex affinity (Kd).
In comparison, vinculin-ΔEx20 causes only moderate changes in number and size of adhesions leading to 13% of relative adhesion area or a 1.4 fold increase with respect to vinculin wild type expression.
As demonstrated by data obtained from ARE-dependent luciferase reporter gene assay and qRT-PCR analysis, a loss of Nrf2 phosphorylation caused only moderate changes in the transcriptional activity of Nrf2 (Figure 2 and 3).
Nasal and tracheal epithelial cells were more resistant to RSV infection and had a higher expression of trkA receptor, but they did not show any significant upregulation of NGF and only moderate changes in BDNF and its receptors.
Compared with the changes of Ins, we found only moderate changes of tCho.
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In the study byRokyta et al. despite induced high variations in temperature setting, only moderate change in cutaneous temp (0.9°C) and limited CT (1.3°C) were observed [17].
De Montfort championed radical reforms that would place further limitations on the authority and power of the major barons as well as the Crown; others, such as Hugh Bigod, promoted only moderate change, while the conservative barons, such as de Clare, expressed concerns about the existing limitations on the King's powers.
In the study byRokyta et al. despite induced high variations in temperature setting, only moderate change in cutaneous temp (0.9°C) and limited CT (1.3°C) were observed [ 17].
But moderate change may not be enough.
As noticed in the experiment shown in Supplementary Figure 4, bortezomib treatment alone shows only very moderate changes in monolayer integrity and cell morphology.
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