However, expression of both genes was only mildly stimulated by BMP-2.
In 3T3 cells, expression of the chloramphenicol acetyltransferase (CAT) from the HIV LTR was also enhanced ∼3 fold by HIC (Fig. 4B) while expression of firefly luciferase from the PCNA promoter, which is only weakly dependent on P-TEFb [11], was only mildly stimulated by HIC (Fig. 4C) or the HIC 3'UTR alone (data not shown).
Thus, promoters that are strongly stimulated by TFEα/β could be downregulated in stationary phase, while expression of TFEα/β unresponsive (or only mildly stimulated) promoters would be less affected.
On the other hand, A+6 was only mildly stimulated by ferrous iron, which would suggest this strain either has additional mutations in genes related to direct ferrous iron transport, defects in global regulators that stimulate up-regulation of iron-acquisition genes under iron starvation [ 24], and/or another non-iron-related dependency on the presence of citrate.
However, tadalafil only mildly stimulates ATPase activity, without reaching the concentration required for 50% stimulation even at highest concentrations used.
On Saturday at London's O2 Arena, Anthony Joshua went from mildly stimulating to eye-poppingly potent.
Yet nicotine attracts nowhere near the concern that cannabis does, in part because the two drugs are so different in their everyday effects: mildly stimulated versus stoned.
In vitro fertilisation with unstimulated or mildly stimulated regimens are becoming more popular.
For example, both UV-B stress after one hour in shoots and drought stress after one hour in roots stimulate only mildly if at all the HCGs of the Asp-family network (Fig. 4), while stimulating much stronger the HCGs of the AAA network (Fig. 5).
Such an integration of the plasmid might have only mildly deleterious effects.
TGF-β1 and IL-10 levels in the supernatants of CD4+CD25+ T cells stimulated with anti-CD3 mAb were only mildly decreased in MRL/ lpr mice compared with MRL/Mp mice, whereas CYC and Y27 significantly increased TGF-β1 and IL-10 production.
