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This is not surprising given the poor efficacy of SP. As a monotherapy, ART is usually taken for 7 days; a 3-day ACT course is only efficacious when the second drug retains adequate efficacy.
However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production.
In addition, when the herniated lesion is migrated upward or downward behind the vertebral body, both approaches, and even anterior cervical discectomy and fusion, are impractical, and corpectomy is commonly considered as the only efficacious treatment.
Given that the currently available treatments to prevent HIV transmission and disease are not effective in eradicating the virus, vaccination likely represents the only efficacious adapted response to the global impact of this infection.
But the market shifted when the FDA decided new drugs had to be not only efficacious, they had to enhance the standard of care.
This is the essential, and after all the only efficacious security for the rights and privileges of the people which is attainable in civil society.
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In 1962 the Food, Drug and Cosmetic Act was amended to require that any new drug should be not only safe but efficacious.
The Kefauver-Harris US Federal Drug Administration FDAamendmentent in the 1960s added the requirement that new drugs prove that they are not only safe, but efficacious.
With an ageing population and increasing rates of chronic disease, switching of patients from intramuscular to oral vitamin B12 replacement appears to be not only clinically efficacious but also an effective use of limited healthcare resources.
SCK NPs with shell silver cation-load only, while efficacious in vitro, failed to demonstrate efficacy in vivo.
Effective disease control with a vaccine requires not only an efficacious vaccine and health system to deliver it, but also recognition among the general population of its benefits and their willingness to use such a vaccine [ 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com