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Vascularisation in human solid tumours is measured in these hot spots, which arise through angiogenesis and ongoing vessel remodelling, and this measure has a widely confirmed prognostic value in breast cancer (Vermeulen et al, 2002).
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Subclinical ongoing large vessel vasculitis can therefore occur and may contribute to the increased risk of PAD in isolated PMR.
Ongoing infection in vessel walls was first thought to be the cause of accelerated atherosclerosis, but this link has never been established [ 4].
Debates regarding the function of peritumoral and intratumoral lymphatic vessels are ongoing.
Inflammation and hypoxia support activation of local blood vessels and ongoing angiogenesis in the synovial membrane, which is an important early step in the pathogenesis of RA [ 5].
Conversely, blockade of VEGF in tumours resulted in a rapid decrease of Dll4 expression in tumour vessels (Noguera-Troise et al, 2006), showing that a significant portion of the Dll4 expression in the growing tumour vessels requires ongoing VEGF signalling.
The current model suggests that autocrine Vegfa is crucial for stimulating VEC survival in response to stress signals such as hypoxia, irradiation and reactive oxygen species, factors that would be ongoing challenges for mature vessels.
The permanent implantation of a stent, a tube-like metal device, immediately following traditional balloon angioplasty provides ongoing mechanical support to the vessel wall.
Factors of importance are ongoing vascularisation processes, variations in vessel wall leakage and changes in blood flow.
It also remains unclear whether the increased CO2 production reflected by the negative AJVD pCO2 counteracts perfusion, metabolism mismatch or contributes to ongoing metabolic impairment due to vessel dilation and subsequent sustained brain swelling with compression of the microcirculation.
Vessel dilation probably indicates ongoing angiogenesis, since it is one of the first steps preceding vessel sprouting.
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