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The advantage may be that miRNA-guided translational repression can uncouple the ongoing translation.
Current research indicates that this tissue engineering approach is safe and effective, and the ongoing translation of this technology holds great promise.
It might not matter for some of the more obscure novels, but Aaeru recently received a cease-and-desist letter from a localization company called MangaGamer (localization companies are essentially professional translators who work directly with Japanese developers) that didn't approve of her ongoing translation of a popular visual novel called Da Capo III.
In other words, altered protein expression by recipient cells could be an ongoing translation of these mRNAs.
Even if ribosomal subunits initially remained membrane-bound upon termination of VSG translation, ongoing translation of cytosolic transcripts would result in a clearance of ribosomes from membranes [35].
Taking together the results obtained in the three different cell-free systems (HeLa, Krebs-2 and RRL), we can hypothesize that HIV-1 PR inhibits efficiently ongoing translation of luc mRNAs by means of the specific inhibition of cap- and poly(A -dependent A -dependent
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We therefore propose that ongoing local translation of mRNA maintains the sensitivity of this subset of nociceptors.
As occurs in the case of 3Cpro [19], HIV-1 PR efficiently inhibits ongoing cellular translation, perhaps due to eIF4GI and PABP cleavage since both factor are essential to circularize mRNAs [30].
The study design already includes an ongoing knowledge translation and exchanges (KTE) component.
DOI: http://dx.doi.org/10.7554/eLife.03971.015 10.7554/eLiFigure71.016 Figure 4 figure supplement 2. Effect of arsenite treatment on ongoing reporter translation.
In the absence of cycloheximide (i.e. with, presumably, ongoing protein translation), a 20 30% loss of AChE is observed (Fig. 5B), which may be the result of the ex-vivo conditions of the experiments including the activation of wound-inducible proteases and depletion of the explants' energy resources.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com