Sentence examples for ongoing selective pressure from inspiring English sources

In this way and as indicated by the selection analyses performed [ 75], there is ongoing selective pressure on certain RHDV strains, and consequently the fixation of favourable mutations or the purging of deleterious variants would result in the strong decrease in the relative genetic diversity recently observed for the virus [ 76, 77].

We do not allow for reversion of resistant strains to wild type in the absence of ongoing selective pressure from antiviral drugs.

In addition, we inferred through simulation that the majority of the E. coli strains should have already lost the operon unless there is ongoing selective pressure to maintain it.

We have also detected weak evidence for ongoing selective pressure in the human genome on the STK11 and CDH1, but these signals of selection may be artifacts of the very small effective population size of modern humans.

Five of 16 strains compared in this work still contain at least one of two types of putatively functional CRISPR/Cas systems indicating an ongoing selective pressure by bacteriophages.

Retroviral specificity of TRIM5 dramatically differs among primate orthologs due to ancient and ongoing selective pressures reflected by variation in the Coiled-Coil and B30.2 domains, which influence the interaction with viral proteins (Sawyer et al. 2005; Sebastian and Luban 2005; Kirmaier et al. 2010; Maillard et al. 2010).

RBL1 was analysed in a similar way but showed no evidence of ongoing positive selective pressure.

Such families might be targeted according to their implication in biological processes or molecular functions related to the ongoing natural selective pressure.

Therefore treatment response might be influenced by TDR even after many years, resulting in ongoing viral replication under selective pressure and promoting the evolution of further resistant variants [42].

These data show that a major challenge in gene therapy for HIV infection is to promote regeneration and expansion of the gene-protected CD4+ T cells under the selective pressure of ongoing virus replication, a hostile environment for T cell regeneration.

But primary or eventual on-therapy resistance ultimately occurs, likely due to selective pressure from ongoing therapy, which can lead to transformation to a ligand-independent state [ 22].