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The evaluation of exploratory search relies on the ongoing paradigm shift from focusing on the search algorithm to focusing on the interactive process.
From a sclerosant standpoint, there is an ongoing paradigm shift toward foam-state sclerosant mixture in Japan and the United States (as of 2006).
This ongoing paradigm shift in AD definition and diagnosis represents a fundamental basis for redefinition of interventional trials in AD, allowing to specifically focus on preventative measures during very early pathophysiologically confirmed stages of disease.
Although resistance to change is hard to overcome, there is an ongoing paradigm shift.
Understanding drug movement in association with its size at the single-molecule level and estimating the time needed to reach the targeted organ is indispensable for optimizing drug delivery because single cell-targeted therapy is the ongoing paradigm.
We also point out here that within neuropsychology there is an ongoing paradigm shift from identifying foci of abnormalities to delineating the functional connectivity among several brain regions, towards developing a global understanding of aberrations at the level of large-scale, whole brain networks.
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Due to these suboptimal results, there is a paradigm shift ongoing from the "transtibial" towards the "anatomic" ACL reconstruction technique (Yasuda et al. 2004; Mae et al. 2010; van Eck et al. 2010; Chechik et al. 2013).
As such, this creates a potential conflict for the Rb-E2F transcriptional induction paradigm, where ongoing late-G1 de novo transcription is thought to be required for G1-S transit (and consequently also for preRC assembly).
Studies are ongoing in defining valid paradigms for specific imaging and/or quantitative applications of the DH methods in biology: this requires efforts in comparative studies using a strict interdisciplinar cooperation between experts in life-science and optics.
The Dark Energy Survey DESS), an international collaborative of over 400 scientists working on universal cosmology, is hoping to rupture this paradigm in their ongoing exhibition at Fermilab Art Gallery, titled Art of Darkness.
However, in recent years a paradigm shift is ongoing in the United States toward using sensitive and specific enzyme immunoassays (EIAs) and chemiluminescence assays for screening [ 13].
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