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We excluded hospitals that transferred patients requiring ongoing mechanical ventilation, even if they provided short-term care to postoperative ventilated patients and those patients requiring stabilization prior to transfer.
However, during ongoing mechanical ventilation, (dynamic) end-inspiratory airway pressure exceeds (static) plateau airway pressure, especially when inspiratory flows are very high [2].
Prolonged ARDS requiring ongoing mechanical ventilation can induce lung fibrosis, which is a significant contributor to poor outcome in ARDS [25].
However, the ongoing mechanical ventilation resulted in fragmentation of both GAGs, leading to ECM disorganization.
The majority of patients (80%) were intubated in the operating room and transferred postoperatively to the ICU for ongoing mechanical ventilation.
Twenty-nine of the 30 acute care hospitals (97%) that did not provide ongoing mechanical ventilation were critical access hospitals, which by definition have 25 beds or fewer.
Similar(52)
Recognizing no uniformly accepted definition, we used a sensitive definition of ICU and subsequently determined capacity for ongoing invasive mechanical ventilation in an ICU (that is, not the emergency department or post-anesthetic care unit) (see Additional file 1).
Persistent acute respiratory distress syndrome (ARDS) is characterized by excessive fibroproliferation, ongoing inflammation, prolonged mechanical ventilation, and a substantial risk of death.
Asphyxia was considered to be present if at least one of the following criteria was met: Apgar score of ≤ 5 at 10 minutes, at least one cord pH or arterial pH ≤ 7.1 or base deficit ≥ 12 within the first hour of life, ongoing resuscitation or mechanical ventilation at 10 minutes of life.
We include adults in intensive care units (ICUs) who (1) have had a request for a first RBC unit transfusion during the first 7 days of ICU admission and (2) have an anticipated requirement for ongoing invasive and noninvasive mechanical ventilation exceeding 48 hours.
During the whole time the ECD was in place, a cisatracurium infusion was ongoing for optimization of mechanical ventilation.
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