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Thus, PPARγ activity is required for glycolysis and ongoing cell division in CGNPs.
Human telomeres progressively shorten with ongoing cell division until they reach a critical length that induces replicative senescence [ 2].
If such non-integrated viral DNA was abundant in cell cultures transduced with the d2 × 250 bp and the 1.2 kb.CMV vectors, titer determination using real-time PCR 3 days after transduction would overestimate the titers, compared to titer determination conducted 7 days post-transduction, where non-integrated viral DNA will be more diluted due to ongoing cell division.
It is known that the concentration of morpholino oligonucleotides per cell decreases with ongoing cell division and the knock-down effect may therefore diverge between tissues as development proceeds (Bill et al., 2009; Eisen and Smith, 2008; Sumanas and Larson, 2002).
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DOI: http://dx.doi.org/10.7554/eLife.07025.016 Given that early and late progeny cell fates failed to be specified and adopted in mex3-1 RNAi) animals despite ongoing stem cell divisions, we hypothesized that there was a loss in stem cell lineage asymmetry in favor of stem cell self-renewal.
The majority of antibiotics, including β-lactams and quinolones, require ongoing cell activity and cell division to achieve rapid killing [18] [21].
Replicative aging, on the other hand, reflects the ability of a cell (and its lineage) to support ongoing rounds of cell division, and is of major importance in organisms whose adult bodies depend on extensive tissue turnover.
The objective of the current study was to investigate if the antimitotic effect of colchicine (CLC) abolishes this resiliency to CD + CCl4 by inhibiting ongoing and stimulated cell division.
We suspect that the mixed clones are likely the result of sorting multiple cells into a single well during the FACS process or ongoing pCas9 activity after cell division, resulting in different mutations in each daughter cell.
These findings underscore the importance of ongoing and toxicant-stimulated cell division and tissue repair mechanisms in hepatotoxicity, and the need for the inclusion of age factors in risk assessment of exposure to environmental and other chemicals.
When an exponentially growing cell culture is treated with rifampicin and cephalexin, new initiations and cell division are inhibited while ongoing rounds of replication are allowed to finish.
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