Three hundred and eighty-three Y. pestis strains from eighteen different natural plague foci in China were identified as Y. pestis by bacteriophage lysis using phage YP-ChinaPhage1 (unpublished assay, ongoing phage sequencing project).
Although there is an ongoing debate which assays are best to quantify these alterations, we made an effort to assess the functional consequences of PINK1 deficiency for both motor and non-motor nervous system deficits as well as growth and survival of the whole organism, using homozygous mutant and wildtype cohorts in pure 129/SvEv background, both derived from the founding heterozygous animals.
Discussion is ongoing regarding the optimal assay parameters (e.g., window periods, cutoff values, including use of a "grey zone" instead of a single value) for a combined BED/Ax-AI algorithm.
Phase 1 also includes ongoing refinement of the assay's technical performance.
Here, we exploited its well characterized effects [ 1 3] to validate a novel human in vivo assay of ongoing synaptic [ 4, 5] processing.
Clinical validation of this assay is ongoing in a population-based study in China, and preliminary results suggested that the OncoE6 has better specificity than Hybrid Capture 2 (98.9% versus 86.8%, resp).
An ongoing study using this assay has simultaneously detected and confirmed influenza A(H3N2), pH1N1, and influenza B viruses in >100 nasopharyngeal swab samples (J. Zhao et al., unpub. data).
Two years since its inception, the ITN now has approximately 2 dozen clinical trials or tolerance assays studies ongoing or in later stages of protocol development.
As of November 2015, 6,189 healthy blood donors have been enrolled in project A-1 and 2,532 cancer patients in project B. Clinical follow-up and biological assays are ongoing.
Immunophenotype analyses have demonstrated that this cell is distinct from other stem cells currently reported in the literature, and genetic and functional assays are ongoing to ascertain the potential of the cell to be used as a treatment for various disease states.
