Sentence examples for ongoing activation from inspiring English sources

In the absence of oncogenic Ras and Raf mutations, other oncogenic events that engage the Ras/MAPK pathway are also likely to stimulate normal feedback mechanisms that may increase the activity of various intermediaries in the Ras/MAPK signalling module, thereby promoting the ongoing activation of ERK kinase signalling.

HIV-infection is associated with ongoing activation of the immune system and persistent inflammation.

On the other hand, thrombin can become deleterious if ongoing activation of the coagulation, owing to defective natural anticoagulants, leads to excessive thrombin formation.

An early loss of gut mucosal integrity, the pro-inflammatory cytokine milieu, co-infections and later, marked destruction of lymph node architecture are all factors contributing to the ongoing activation of both the innate and adaptive immune systems.

4. A similar conclusion can be drawn from the cross-country analysis of the impact of ALMPs on unemployment dynamics, i.e., the inflow (outflow) rate to (from) unemployment in OECD (OECD 2009, Chapter 1). 5. See OECD (2013a, Chapter 3) for an overview of the lessons from the ongoing activation reviews.

First, the ongoing activation of microglia and astrocytes may eventually cause a 'scar' around the electrodes and thereby displace the neurons to be recorded from or to be stimulated.

However, the relative contributions of each of these mechanisms to ongoing immune activation remain to be determined.

Differential expression of proteins in particular from mature enterocytes, neutrophils, and plasma cells could distinguish untreated from treated CD mucosa, and Ig variable region IGHV5-51 expression was found to serve as a CD-specific marker of ongoing immune activation.

Thus, in the presence of ongoing complement activation, the deposition of serum IgA1 antibodies enabled the co-deposited IgG1 antibodies to better maintain their ability to interact with antigens.

HIV-1 elicits vigorous humoral and cell-mediated responses: these fail to clear the infection but contain viral replication for several years, at the expense of ongoing immune activation and CD4+ T cell loss.

Emerging details of disease pathogenesis support the current concept that ongoing immune activation in IBD is driven by bacterial microbiota, possibly as a result to an attenuated antimicrobial barrier in genetically predisposed individuals [1] [3].