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In other words: what is the most likely biological origin of the pattern of gene-gene expression similarities we see probing only the "layer" of transcripts without adding any a priori information neither on the "upstream" regulatory interactions (like a direct transcriptional activation could be considered) nor in the "downstream" ones (at the level of protein or of metabolic interactions)?
The AP-HP experience shows that a multifaceted, sustained and coordinated strategy can lead to control MDR, including the most resistant emerging ones, at the level of a large regional multihospital institution.
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"Americans are here, but not one at the level of the vice president or secretary of state," observed the National Review's Jay Nordinglinger, referring to the presence of Dick Cheney last year and Colin Powell the year before.
Alternatively, it is also possible that progressive inhibition of NF-κB after its peak of activation also contributes to turn JunB from an transcriptional activator state into a repressor one at the level of proinflammatory cytokine genes.
At the start of corticogenesis, two streams of migrating neurons are evident: a superficial one at the level of the preplate (PPL), and a deeper one at the level of the intermediate zone (IZ).
These results do not exclude the possibility that the three SNP promoter haplotype and the DNR regulate gene expression synergistically, one at the level of transcription and one at the level of translation influenced by mTOR signaling.
Patient socioeconomic background was proxied by three variables available at the individual level and one at the level of the statistical sector.
Two velocity-encoded images were obtained: one perpendicular to the aorta at the level of the pulmonary trunk, and one at the level of the abdominal descending aorta 7.5 cm beneath the diaphragm.
Actual radiographic findings revealed 10 malpositions, three of which were too high and seven were too low (one at the level of the carina).
GISTIC produces two levels of q-values – one at the level of probes (given in Additional file 7: Table S5 ) and a second one at the level of peaks, which are contiguous genomic regions spanning one or more genes (given in Additional file 8: Table S6 and Additional file 9: Table S7).
In this study, we made extensive lesions of the corticospinal tract on one side at the level of the medulla.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com