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Although the long half-life of palonosetron allows one-time dosing even when prolonged inhibition of 5-HT3 receptoverover multiple days is desired (eg, to control delayed CINV), it is unlikely that the long half-life alone can account for the persistent superiority of palonosetron when used in combination with an NK-1 receptor antagonist.
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Today, there is a rather greater emphasis on developing drugs that eradicate these infectious organisms with a single, one-time dose than there is on experiments that focus on the basic science of the disease.
In a landmark study of the effect of a one-time dose of the antibiotic streptomycin on the gut metabolome of mice, Antunes et al. showed that over 80% of the detectable metabolites in feces showed altered abundance compared with those in the non-treated communities.
We investigated the ability of a furosemide stress test (FST) (one-time dose of 1.0 or 1.5 mg/kg depending on prior furosemide-exposure) to predict the development of AKIN Stage-III in 2 cohorts of critically ill subjects with early AKI.
S/P is a one-time dose.
In all three experiments, the children received only small, one-time doses of fenfluramine, so experts in the use of that drug say it is unlikely their hearts were damaged.
Wounds were harvested upon complete wound closure (postoperative day 15) for histological examination and biomechanical testing of scar tissue.RESULTS: A one-time dose of 3.90 mM doxycycline (2 mg/mL) within 12 hours of injury was found to significantly reduce scar thickness by 24.8% (P < 0.0001) without compromising tensile strength.
A one-time dose of cash, cows, goats, or other assets and services made families healthier and better off for at least a year, researchers found.
A one-time dose given in the thigh, the vitamin K shot protects infants until 4-6 mofths of age, when they start consuming sources of the vitamin in solid food and when beneficial bacteria that produce vitamin K populate the intestines.
Rather than a high concentration, one-time dose of marketing, such as an Olympic campaign, our findings suggest that long-term brand-building, as well as developing a consumer centric point of sale, are the two critical points in convincing consumers to buy a certain brand or product.
All annual flu shots are covered under Medicare Part B. Td/Tdap (tetanus, diphtheria, pertussis): A one-time dose of the Tdap vaccine, which covers tetanus, diphtheria and pertussis (whooping cough) is recommended to all adults.
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