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Local, one-time administration of a neutralizing anti-EPO antibody, soluble EPO receptor, or an inhibitor of Jak2, a cytoplasmic tyrosine kinase essential for EPO-mediated mitogenesis, resulted in a delay in tumor growth with 45% reduction in maximal tumor depth in tumor Z-chambers in a dose-dependent manner.
One-time administration of hyperoxygenation, intended as a pre-conditioning treatment before induction of myocardial injury, has been shown to be beneficial (Cabigas et al, 2006; Yogaratnam et al, 2008, 2010).
Treatment with abatacept on the other hand resulted in a small, albeit not significant, reduction in disease severity and one-time administration of zoledronic acid showed no protective effect.
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Structured questionnaires were developed for one-time administration to both pregnant teenagers (aged less than 20 years) and the partners of pregnant teenagers.
Like GPI-induced arthritis, one time administration of anti-IL-17 mAb on day 7 and three times administration on day 6, 8 and 10 significantly ameliorated the arthritis.
Patients received a one-time subcutaneous administration of BTX-A using "follow the pain" method.
In particular, the agency took note of the administration's reliance on one-time transfers of money to fill gaps in the state's $32 billion budget.
With one-time streptomycin administration in mice, the number of bacteria in the feces dropped 90% in the first 12 h, but rebounded to pre-treatment amounts by six days post-treatment.
The MTD of the TSRDN gavage for 7 days consecutively after one-time drug administration was 0.42 g/kg/d.
In this case, he shifted $3 billion in highway tolls and other money originally earmarked for the tunnel to plug various budget holes — the biggest one-time fix of his administration.
Two other studies have evaluated the effects of acute, one-time, GLP-1 administration on endothelial function in patients with IGT and T2DM [ 9, 19].
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