Failure of the three LCP constructs occurred at least one test stage later than the corresponding LC-DCP constructs.
Though she had other male friends, including, at one stage, William Wilberforce and, later, Coleridge, her brother was the centre of her life, the one in whom she lived and moved and had her being.
Various means of capturing this were trialled and then discarded or modified (for example, key components were at one stage depicted as interlocking cogs but later discarded as it drew criticisms of appearing too mechanistic).
In brief, binding of the ATP involving conserved Arg residues forming a 'basic clamp' brings NTD and CTD from one subunit closer together (a 'closure' stage later released upon ATP hydrolysis), driving a 'swinging' motion of the neighbouring subunit CTD with some residues moving tens of Å (Satyshur et al., 2007; Reindl et al., 2013).
Most pigs contained more than two different alleles, suggesting that the Cas9-mediated DNA cleavage may occur at embryonic stage later than the one-cell stage, as previously observed with ZFN, TALEN and CRISPR-mediated targeting.
One stage Ib individual developed recurrent tumors 2 years later and underwent pulmonary resection again.
The FTSE 100 recovered some ground later on, having been more than 5% down at one stage.
Later he added, "This is just one stage of many stages to retool this part of the state".
A well-designed decision process can involve incurring transaction costs at one stage in order to save transaction costs at a later stage.
At one stage, sterling dipped below $1.30 and threatened to reach a post-Brexit vote low, before later rallying.
