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We therefore hypothesized that the sister kinetochores on one homolog, which normally attach to only one spindle pole, were pulled in opposite direction.
Later during mitosis, the incorporated sperm axoneme associates with one spindle pole34,36.
Operations of the same block are performed by one spindle head.
In vivo, the DC recruited PCM, formed a daughter centriole, and localized to one spindle pole in the zygote.
EM revealed that one spindle pole body of the duplicated pair appears to be defective for the nucleation of microtubules.
To find the intensity of centromere and kinetochore proteins the 3D positions of all foci were logged using an in-house macro in a pair-wise manner such that both foci belonging to the same bivalent were assessed consecutively and the side facing one spindle pole was always logged first.
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When cultured in DMEM supplemented with 10% FBS, untreated MDA-MB-231 cells display two distinct cell types, one spindle-shaped and the other more rounded.
Then he arrived in San Francisco, where, at a small shop named Columbus Cutlery, an elderly Italian man led him into a room outfitted with a variety of sharpening wheels, all slowly turning on one big spindle.
Based on one significant assumption, spindle orientation defects can lead to cell number increase by suppressing the asymmetric division of stem cells while promoting their symmetric proliferation [ 12, 13].
Kinesin Eg5 is one fundamental spindle motor protein and its specific role during mitosis in the assembly and maintenance of the bipolar spindle has rendered it an attractive therapeutic target that could prevent cell cycle progression through mitosis and promote tumor growth regression [ 8- 10].
The workpiece is moved from one drilling spindle to the next, where sequential machining operations are performed by one or more operators.
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