Unfortunately, no argument or data determines one single correct threshold for what constitutes present/absent for protein disorder.
As mentioned before, the traditional filtering method of using one single global threshold for multiplicity cannot separate correct k-mers sampled from low-expressed transcripts from erroneous k-mers sampled from high-expressed transcripts, and single-cell genome assemblers calculating local thresholds from nearby k-mers may remove many correct k-mers.
Thus, identification of thresholds mainly relies on one single microvascular complication which covers only a small part of the burden of type 2 diabetes mellitus complications.
Often, experiments are used to find a lifetime for one single design and this threshold is assumed to hold for small design changes tested by means of computations.
As stated by others and in accordance with our results, rSO2 seems more useful when it is used as a dynamic information tool rather than a static one, so that a single threshold rSO2 value might be insufficient to predict outcome [ 10, 11, 22].
Of course, the exact value of all these parameters for one single solution depends on the choice of threshold.
Multiple testing corrections can reduce type 1 errors, but they cannot solve the primary problem, that a single threshold in one analysis cannot distinguish between noise and signal of the same magnitude.
One limitation of using a single threshold is that it removes data regarding just how heavily students actually drink (Alexander and Bowen 2004; Read et al. 2008) and assigns the same level of risk to all students who cross the thresholds regardless of how far beyond the threshold they go.
Considering a genome-wide significance threshold of p ≤ 5 × 10−8, only one single nucleotide polymorphism (SNP; rs1835740) was significantly associated with overall migraine.
The single threshold was evaluated because some studies use only one threshold for segmenting WMLs in all patients [ 2].
Figure 8c shows the object segmentation by single threshold, as we can see from this picture, only one threshold is not enough to segment the whole object when the background is with high modulation level.
