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Thus, the beneficial effect of one single dose of db-cAMP on the proteasome effectively prevented protein aggregation upon short-term but not long-term treatment with PGJ2.
Our results show that human SCC of the skin can be selectively targeted by SIPs and that human skin tumours implanted in nude mice can be ablated in a curative manner by one single dose of immuno-PDT based on a vascular targeting antibody PS conjugate.
In that study, 533 patients with colorectal cancer about to undergo curative resection were randomly assigned no adjuvant treatment (control group) or an immediate postoperative infusion with 5FU (500 mg m−2) for 7 days, with one single dose of mitomycin (10 mg m−2) on day 1.
One single dose of nicotine (Sigma) diluted in sterile PBS (Phosphate-buffered saline, pH 7.2) was injected intraperitoneally 30 minutes before surgery in either sham-operated group or mice undergoing renal I/R.
One single dose of 2 × 10 UCMSCs was infused into the MCA.
All pts received one single dose of 1 g meropenem intravenously.
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For logistic reasons most clinicians (both in human and in veterinary medicine) strongly prefer to apply one single dose instead of daily injections over five or ten consecutive working days.
One single dose was sufficient in 37 of 67 (55.2%) episodes.
The effects of one large single dose of 5-fluorouracil (FU) have been compared to the same amount given in divided doses daily over a 3- or 5-day period.
One single-dose study of 16 volunteers between ages 65to8585 confirmed this by finding that TPM clearance was reduced by about 20% when compared to 16 younger adult controls.
There's just one catch: a single dose of the drug costs a thousand dollars, which means that a full, twelve-week course of treatment comes to more than eighty grand.
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CEO of Professional Science Editing for Scientists @ prosciediting.com