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Additionally, we have that there exists one single agent per each possible case that our model considers (or that the population is equally distributed among those cases).
Moreover, the responses to one single agent for two different headache syndromes in our patient and in Rozen's case report suggests that the dose of previously effective drug should be increased (rather than to add new drug) for the change in the pattern of headache and for co existence of two different types of headache syndrome at the same time.
Because no one single agent works.
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One SD was achieved in a patient progressing on single agent carboplatin.
One single-agent study with gemcitabine at 1200 mg m−2 days 1, 8 and 15 q 4 weeks, failed to demonstrate objective response in 23 patients (Smorenburg et al, 2001).
SD was achieved in one patient progressing on single-agent carboplatin at study entry.
Three phase III studies examining the addition of sunitinib to chemotherapy [ 44– 46], and one comparing single agent sunitinib versus chemotherapy [ 47], all failed to demonstrate improvement in PFS or OS.
24, 25 In one study, single agent PLD, administered at a dose of 50 mg/m (every-4-week schedule) was compared with single agent gemcitabine, 24 while in the second study, PLD was administered at a dose of 40 mg/m (every-4-week schedule) and again compared with gemcitabine.
The other day I spent more than a day's wages on a (as in one single) bra from Agent Provocateur.
Currently, investigations have progressed to confirmatory Phase IIIb clinical trials for the treatment of unresectable MM, one as a single agent [ 17] and another in combination with doxorubicin.
The current questions regarding palliative chemotherapy in the UK remain – is any doublet of the new or old generation better than UK triple therapy for patients of performance status zero or one, and can single agent chemotherapy replace UK triple therapy for patients of performance status two?
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Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com