Lignin side chain oxidation with production of more carbonyl groups in the chewed sample might be one of the contributing factors for the initial thermal degradation stage [ 39], which was also demonstrated by Py-GC/MS.
Since the genes sampled in the present study were identified after sequencing ESTs, one could argue that the sample might be biased towards expression patterns that are possibly related to high sequence conservation (for example, [ 69]), hence artificially increasing the ratio of ancient versus recent gene duplications detected in the present study.
Anomalous TS content observed in one of the samples might be due to an external source and perhaps related to the presence of thermal springs in the region.
Inhibition of the PCR by substances present in stool samples might be one possible explanation.
One might be passion, one might be love, one might be a child.
In this study, KRAS mutation was found in only one MSI-H sample, which might be explained by the fact that our samples are derived from sporadic CRC in which MLH1 promoter methylation is believed to be the main route of tumourigenesis.
One explanation might be the metropolitan sample of the survey.
One reason might be, because this sample is a selected group of cancer patients who would be treated with curative intent.
(For example, a sample recipe might be "one 502g plastic bottle, 212g of grape soda, one 83g red ballpoint pen, 197g of lemonade mix, a 2g gum wrapper, and four 1g black jelly beans").
So instead of having to study 10 SNP's near one another, it might be possible to sample one or two of them to know the whole pattern, thereby cutting the amount of work needed.
