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The phrase "one problem is that" is a perfectly valid and usable part of a sentence.
It is usually used to introduce there being a problem or issue with something. You can use it in both formal and informal writing, for example: "One problem is that many people are unaware of the long-term health risks associated with smoking."
Idiom
Problem is thirty.
If a problem is 30, the problem is the person who sits 30 cm from the computer screen.
Exact(60)
One problem is that Lansley speaks largely in jargon.
One problem is that stress can be subjective.
One problem is that golf is expensive: the median fee for 18 holes is $40.
One problem is that labour is extremely expensive in this Arctic wilderness.
One problem is that QE mainly works via lower bond yields.
One problem is that Harriet is more a conceit than a character.
One problem is that inflation has risen steadily in recent months, to 3.9%.
One problem is that Symmetrix is getting long in the tooth.
One problem is that tcatch-up does not occur if there is overdiagnosis.
One problem is that plasmids carrying exogenous genes (arsM genes) are often lost during practical application.
One problem is that reads from two genomic strands are not complementary at methylated loci.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com