Across the three genes and four traits within Exp. 1, 13 polymorphisms were consistent across the three methods, while one polymorphism was identified by both GLM and MLM, 3 by both GLM and Logistic Regression.
Genome-wide association studies (GWAS) of 55,977 single-nucleotide polymorphisms identified in one or more strains found one highly significant association (P = 8.78E-08) between a nonsynonymous mutation at codon 481 (H481) of the rpoB gene and increased vancomycin MIC.
Because the Hp1/2 polymorphism was one of the first protein polymorphisms identified, there is a considerable amount of population allele frequency data published that has recently been summarised in a review (Carter and Worwood 2007).
One such deviation is population growth, which tends to increase the number of singletons η 1 present in a sample (i.e., derived polymorphisms identified in only one individual).
We compared the frequency of polymorphisms identified in at least one test for selection in fish collected from New Bedford Harbor and Scorton Creek, Massachusetts.
Indeed, we identified one polymorphism initially segregating in the F252 seed lot at a candidate locus for flowering time, which explained 35% of the trait variation within the Late F252 population.
Of the known polymorphisms identified in the present study, D418D (rs2071313) was the only one absent in the controls whereas H433H (rs540012) and A541T (rs2959656) were present in all the controls indicating that these polymorphisms may not be associated with increased tumor risk.
A previous study investigating mutations in GLI3 exons 9, 10, 11 and 12 identified only one polymorphism [ 26].
The first arthritis regulating QTL to be cloned and positioned to one polymorphism is the Pia4, which was identified to be regulating chronic inflammation by a non-synonymous SNV in the Ncf1 gene, altering the amino acid at position 153 [ 52].
One previously identified polymorphism in DDR1, located at amino acid 495, was identified in 46% of the clinical samples screened.
