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No type of serious adverse event occurred in more than one patient except for P. falciparum infection, which was reported by investigators as a serious adverse event in two patients.
In all patients, except one patient with HAP, infection was adequately controlled on Day 3 according to the attending physician.
All except one patient were mechanically ventilated, and all except one patient received vasopressors and/or inotropes.
The formation of HAMA and HACPG2A occurred in all patients except one (Patient no. 13 no HACPG2A formation).
All patients except one (patient #13) developed a positive HACPG2A response.
All patients except one patient (Case A7) had hypotonic maculopathy before the treatment.
All other patients, except one patient in the phase I portion of this study, were followed up.
None of the patients except one patient of the NMV group who was receiving treatment with bortezomib were under immunosuppressory therapy by the day of admission.
Ki-67 labeling index was less than 1%% in large proportion of pancreatic PEComa patients including our patient except for one patient with less than 5%%.
Except one patient, left atrial volumes were calculated on the basis of contrast enhanced CT data.
Accordingly, chemotherapy could be fully administered on days 1 and 8 to all except one patient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com