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The range of secondary analyses by making use of clinical trial data may, however, also include analyses based on data coming exclusively from one particular trial, with the goal to add new or challenge existing claims.
In one particular trial, a man from a European country who had been in England for a decade was charged with failing to notify a local government department of changes to his child tax credits, which altered his entitlements to various benefits and local tax allowances.
In one particular trial the mean 25(OH D in the north was 17 ng/ml versus 38 ng/ml in the south.
However, one particular trial published some 10 years ago marked an important turning point for the orthopedic community as a whole.
The latter strategy is recommended within Steyerberg et al. [ 18], where they propose others apply their model using the intercept for one particular trial in their analysis, as this trial is reflective of the population intended.
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I needed advice about one particular clinical trial.
We focus on one particular sort of collaboration, that of group work around a clinical trial protocol, where the collaboration is asynchronous and the participants are geographically distributed.
I've got one particular colleague on this trial, who shall remain nameless, who is very strong on the quantitative side, who grudgingly has come to accept that qualitative research might have some role as a sort of preliminary to other things, but I can't really shift his main thinking, which is that science is really about hypotheses and testing hypotheses rigorously.
For example, if in a clinical trial comparing different types of hip replacement all of the missing data occurs in one particular arm of the trial, the remaining data is unlikely to be representative of the overall result in that group of patients; the missing data may be because those patients went to another hospital for their revision surgery.
Almost anytime the subject of women in Silicon Valley comes up, people return to one particular case: the 2015 trial involving Ellen Pao.
Although all randomized controlled clinical trials share basic design characteristics, to assess the outcome of a particular trial one must carefully evaluate specific details of its design and analysis that might bias the study and influence its results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com