Your English writing platform
Discover LudwigSuggestions(1)
Exact(1)
Another striking outcome is that although the stability of XCI in EpiSCs has been unknown so far, we find that the Xi of EpiSCs can be reactivated by nuclear transfer to Xenopus oocytes, unlike the one of differentiated cells.
Similar(11)
Hybridisation introgression is the permanent incorporation of genes from one set of differentiated populations into another [59].
One hallmark of differentiated pituitary cells is their responsiveness to hypothalamic hormones and the ensuing production of pituitary hormones.
Many stem cells have the potential to generate more than one type of differentiated progeny (i.e. they are multipotent).
Using approaches similar to the iPS technique, scientists have been able to convert one type of differentiated somatic cells into another type, without going through the pluripotent stage.
More recently, reprogramming adult differentiated cells to a pluripotent state (iPS) became possible, and later, one type of differentiated cell could be directly reprogrammed into another (e.g. fibroblasts into neurons) without reverting to pluripotency.
Although these culture conditions give rise to only one subset of differentiated cells and do not represent the full heterogeneity of macrophages or DCs in vivo, it still is the most efficient way to obtain human antigen presenting cells.
Intriguingly, we find these tradeoffs can be alleviated through an alternate strategy that we refer to as fate control, whereby lineages branch - that is, stem or progenitor cells produce more than one type of differentiated product - and the branching decision becomes the target of feedback control.
Note that differentiation can lead to any one of the differentiated cell types, with probabilities commensurate with the tissue composition.
When a progenitor cell differentiates, it transitions from the initial indeterminate state into one of two differentiated states with high expression levels of either gene GATA-1 or PU.1.
One of the differentiated characteristics of VTA neurons conferred by Otx2 is higher resistance to MPTP.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com