Sentence examples for one obvious issue is from inspiring English sources

One obvious issue is expense.

One obvious issue is that we used only pilocarpine as a model of seizures.

One obvious issue is the inflammatory reaction and subsequent scarring that is induced by chamber insertion.

Back then, the most obvious issue was a pragmatic one, of air-conditioning in Philadelphia, where both parties met: workers dragged fifty-pound ice blocks up to the roof, where they promptly melted.

One obvious issue with yap.TV is spoilers — it isn't unusual for people to tweet about major plot points, which can screw things up if you're on the West coast or anywhere else with a time delay.

One obvious issue with our redesigned prototype was the inability of all but one PCP to recognize that the specific results of abnormal tests (i.e., colonoscopy pathology reports) were available from the timeline by clicking on a green box (see Figure 3).

One obvious move is to issue a blanket rule that auditors cannot provide companies whose books they police with any other services.

One obvious explanation is copy number variation.

One obvious reason is proximity.

One obvious difference is size.

One obvious problem is sequencing.