Of the 79 patients in the United States that underwent CT scans, 78 had a positive scan and one had a negative scan.
One patient with a negative scan showed entirely negative tumour cells, and the other showed occasionally positive cells (Table 4, Fig. 3).
Of the two patients who had a negative scan, one was repeated after the fourth cycle of R-CHOP and was again negative; the FDG-PET was not repeated in the other patient.
An explanation might be that of the three studies included in this subgroup analysis, Piccardo 2012 reported on just one patient with a false negative scan, resulting in a sensitivity of 0%.
Seven of the 23 patients (30%) who underwent FDG-PET after the second or fourth cycle of R-CHOP had a negative scan at one or both time points.
Both SST-scan as well as CT indicated disease persistance in one case, while negative scans corresponding to complete remission as judged by conventional staging were obtained following therapy in the remaining patients, and absence of relapse has been confirmed for a median follow-up of 2 years.
During positive scan the curves were split into two peaks while negative scan shows only one sharp peak.
The odds of endometrial cancer after a negative scan (endometrial thickness ≤ 4 mm) are only one-tenth of the odds before the scan [ 4, 5].
These show that there is only one irreversible peak, located at −1.2 V, in the CVs from the positive to negative scan direction, at a scan rate of 10 mV/s (Fig. 3, curve a).
One negative comment outweighs 1,000 positive ones".
