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Dr B The purist's goal is to try to establish a bacteriologic diagnosis, but the realization is that one must initially treat broadly because no single test has the sensitivity and specificity to allow one to treat narrowly.
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In order to act, one must initiate one's action.
Intrinsic to any statistical inference, initially one must select an appropriate method of inference based on the available source of training data and clinical endpoints (e.g., steps (1) and (2)).
In GRADE, one must give high priority to randomization: RCTs are initially judged as two levels stronger than observational studies, and three levels stronger than other study designs.
However, one must keep in mind that E-PIX was initially developed for use in an application where integration into the existing clinical IT infrastructure was important and no significant network limitations (bandwidth, latency) had to be considered.
Manufacturers must initially enhance and then supplant legacy systems with intelligent, cloud-based ones — opening a Pandora's box of security and interoperability challenges.
One must note that the systolic blood pressure used for matching referred to the blood pressure that was initially measured at the accident site.
One must die, one must live".
One must not romanticize.
One must be careful what one says.
One mustn't cover one's face.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com