One large concern about the use of ZFNs, TALENs and CRISPRs – all of which are designed, after all, to introduce DSBs into genomic DNA – is that they will not only cleave at 'on-target' sites but also at 'off-target' sites.
Markets were initially calmed by reports that one large pipeline concern, Kinder Morgan, had indicated that its Plantation pipeline, running from New Orleans to the East Coast, was undamaged and expected to resume operating by Tuesday.
This addresses one of the larger concerns among Walmart's core demographic, who may be more concerned with cost than convenience.
This addresses one of the larger concerns among Walmart's core demographic, who may be more concerned with cost than convenience.
One of the larger concerns has been that mandatory quarantines will prevent healthcare workers from offering their critical skills to response efforts in West Africa.
But, if the history of black athletes is indicative, the larger concern is how one could not have known this to be the case all along.
Of larger concern is Kirk.
Shuwa Corp., which owns Arco Plaza in Los Angeles and more than 30 other buildings in the United States, has caused a minor sensation here by accumulating large stakes in two regional supermarket chains and talking boldly about combining their operations into one large and efficient retailing concern--against the wishes of the companies' managers.
Our evaluations are based on dose response data for single chemicals and mixtures from one large study and therefore substantiate concerns about the synergistic induction of genital malformations by antiandrogens with mixed modes of action.
Regardless of the etiology, the shift in practice towards earlier dialysis initiation is concerning given that one large randomized controlled trial and several observational studies have failed to demonstrate any mortality benefit with earlier dialysis initiation [ 1, 8, 9].
