This model takes an individual-based approach where all members of the prey population are "copies" of one individual, and each "copy", could be the "model individual" itself.
For example, if one individual carries one copy of haplotype A and one copy of haplotype B, the coding for haplotype A and B would be one, and the coding for the rest of the haplotypes could be zero.
During copy number analysis across the CFHR locus we noted uncommon but previously reported variation, including one individual with three copies of the CFHR3 and CFHR1 genes, most probably a result of duplication of theses genes on one allele 29– 30.
In this analysis, we noted one individual with three copies of CFHR3-1, suggesting duplication of these genes on one allele.
Brown et al. [ 2] first discovered subtelomeric variability in the humans, demonstrating that some human subtelomeric block, analysed by FISH in more than one individual, showed variation in copy number and chromosomal location [ 2, 9].
Hence, within a large out-breeding population, the chance that one individual will carry two copies of an inactivated gene will be very low.
For example, rawCNVEs 5.1, 5.2 and 5.3 all showed decreased signal indicating a decrease in copy number in one individual (Fig. 2d), and increased signal and copy number in a different individual (Fig. 2f).
Moreover, even with dramatically reduced DNA sequencing costs, the high costs of data interpretation subsequent to the tremendous bioinformatics effort of analyzing 6.2 Gb nucleotides of two copies of one individual genome means that personal genome sequencing will not become clinically routine in the near future.
Most importantly, inheriting two copies IBD by one individual becomes much more unlikely to occur by chance than sharing a single haplotype.
There were 52 unique COII haplotypes, with one individual (Lillburn Cave) having two highly divergent copies.
