One important one is bargaining theory.
It is believed that increased free radical generation is one important mechanism that promotes the progression of chronic inflammation into malignant transformation (Hussain et al, 2003).
Several factors may play a role, but one important reason for this disease progression is likely to be the delay in diagnosis.
As genetic instability altering with disease progression is one important character of malignant tumour, it is possible that nm23-H1 play various roles in the different stages of cancer development.
One important step during cancer formation and progression is loss of the epithelial cell identity and break down of intercellular junctions, which leads to the generation of motile mesenchymal cells.
Because bone cells adapt to habitual loading, one important feature of an exercise program is progression [ 5].
The efficient removal of DNA lesions is one important mechanism to prevent malignant transformation and tumor progression [ 4- 7].
One important factor associated with altered remyelination capacity and disease progression is aging [ 14].
One important issue in the course of CHB is the progression from CHB to cirrhosis and hepatocellular carcinoma.
One important point raised by the authors was that selection by farmers is not always part of a progression towards evolution and changes in gene frequencies.
