Sentence examples for one important problem is that from inspiring English sources

One important problem is that in some cases one may not be able to find evidence that favors a model of a given number of components over another model that contains more or fewer components.

One important problem is the fact that the Gaussian approximation proposed previously provides inaccurate error probability values when the threshold λ in (18) and (19) is far from the mean of the log-likelihood random variable L. Chernoff bound and large deviation theory [16] are preferred in this context as very small error probabilities of types I and II may be desired [17].

One important problem is the following: How are deaminated cytosines that escape repair prior to replication repaired, if at all?

One important problem is how to calibrate such a model.

The more important problem is that "owning" a technology is not an economic relationship, but rather a legal one.

22 One especially important problem is, however, that radical lymph node dissection carries risks of considerable morbidity, which may substantially affect a patient's quality of life.

The problem is that mayoral succession is one of those important but unsexy issues that keeps bouncing around with no one doing anything about it.

One particularly important problem is the quest to develop nanoparticles that support the therapeutic delivery of drugs and macromolecules, inside of specific cell targets, in vivo.

One important problem that arises in such paradigm is the imperfect observations (e.g., sensor readings) that lead to the estimation of the current user situation.

Because of the geology and the soil properties and based on all of the measurements we've taken, basically the whole Indus plain is at high risk of having high arsenic levels in the groundwater". The researchers say that one important cause of the problem is that the sediments that contain the arsenic are relatively young.

One important reason for this problem is that a large multigenerational pedigree is required to conduct a reliable analysis of this trade-off.