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The analysis identified one highly significant QTL on chromosome XV associated with sex that explained 84.7% of the variation (Table 1).
One highly significant SNP was found on BTA4 (47.8 Mbp) in the gene CFTR (cystic fibrosis transmembrane conductance receptor) involved in cystic fibrosis in humans.
Interval mapping using 1994 SNPs detected one highly significant QTL for skin color on the distal portion of chromosome 9, at position 89.5 cM, near SNP 9_30303238.
In S7, only one highly significant QTL for height was identified on SBI-09, while a further 5 significant QTL were identified on SBI-03, SBI-04, SBI-06 and SBI-10 (Additional file 2: Table S7).
Comparing our results with these previous studies, only one highly significant SNP that overlaps with a QTL on GGA3 (between 263 and 282cM; 98.1 and 107.0 Mb), detected by Pinard-van der Laan et al. [ 16] and Bacciu et al. [ 17], was observed.
Four significant (LOD > 2.0) and one highly significant (LOD > 3.0) QTL were detected on chromosomes 3, 10 and 11 using single QTL analysis across both methods.
Similar(32)
In the first one, a highly significant QTL for sex determination was identified [ 19], and in the second one a single QTL for body length was detected [ 20].
This is a total of 37 tests performed on 25 variables, having five significant values, of which one was highly significant (p < 0.001).
The finding of two loci (one highly statistically significant) suggests that additional PD susceptibility genes might be identified through targeted candidate gene studies in these regions.
Only one highly statistically significant value was recognized at the electrode position P4.
While COX2 showed one very highly significant codon, this mutation was only found in a single individual, and hence its importance can not be verified.
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