One envisages that in this cytoplasmic pool, myosin VI is in a folded inactive state with the binding sites on the CBD for its binding partners masked and the actin interface on the motor domain blocked and phosphorylation or increases in Ca2+ concentration and/or binding to cargo or membrane would activate the molecule.
To explain the decrease in TPR of H2 consumption, one can envisage that treatment at temperatures higher than 800 °C, the densification process with sintering and closing of the pores may lead to an entrapment of copper species in the vitreous silica matrix.
Thus, one can envisage that use of lhRNAs designed to efficiently inhibit at least two independent siRNA-susceptible regions may help to delay the onset of HIV-1 escape variants, especially when targeting only conserved sequences [46].
Given the observed complexity of malaria pathogenesis, one might envisage that more network components have yet to be identified.
One could envisage that overproduction of lymphangiogenic factors may provide extra lymphatic channels, thus promoting the spread of tumour cells.
One could envisage that, at a genome wide level, many of these H3K4me3 modifications share the same position in both T cells and CD34+ cells.
One can envisage that except for the crossover to irinotecan-based therapy, second-line, in the control 5-FU/FA arms of all three trials, these differences might have been even greater.
In addition, one can envisage that anticancer peptides, which translocate to the cytosol, interact preferentially with the mitochondrial membrane owing to its high content of negatively charged lipids such as cardiolipin.
One may envisage that compartmentalized xylulose-5-monophosphate pathway enzymes would constitute novel functions which underwent positive selection, leading to a highly regulated peroxisomal pathway as observed herein, while leaving the PPP unaffected.
The one thing absolutely no one envisaged was that Arsène Wenger would still be in place 20 years down the line, not only Arsenal's most successful and long-serving manager but doyen of what he has just described as a "world championship" of leading foreign coaches, an event taking place annually in England that is otherwise known as the Premier League.
