One difficulty with getting a clear reading on Spock comes from his midlife career as a radical peacenik during the many waves of protest against the Vietnam war.
One difficulty with this approach is its reliance on the matrix exponential e m Δ. Identifying general numerical approaches to matrix exponentiation is known to be problematic (Moler and Van Loan, 2003).
One difficulty with adiabatic quantum computation is the limit on the computation time.
One difficulty with these evaluations of the impact of taxon sampling on divergence time estimates is that they were not specifically designed to test this issue and thus are only marginal assessments.
One difficulty with this model is that it is nonregular (the support depends on some parameters) in the case of increasing hazard functions, and therefore the standard maximum likelihood asymptotics do not hold.
One difficulty with Bessemer's process was that it could convert only a pig iron low in phosphorus and sulfur.
Fitzgerald's agent detailed five magazines that rejected the tale, adding: "One difficulty with the story seems to be the threat of suicide all the way through".
One difficulty with these stories, of course, is in knowing how many of them are accurate and how many are merely nostalgic fictions.
The artist Paul Emsley, Glasgow-born, South Africa-reared and winner of the 2007 BP portrait prize, said he had faced one difficulty with the portrait.
One difficulty with entrusting mental-health services to a for-profit company is that there is a disincentive to acknowledge abuse, because doing so could jeopardize the contract.
One difficulty with cost-benefit analysis is that every government agency has an incentive to estimate favourable ratios for its own projects.
